Acral lymphomatoid papulosis (a-LyP) is a rare clinical variant of LyP whose diagnosis may be challenging. A case series of a-LyP was studied clinically, histopathologically, immunohistochemically, and from molecular point of view. Including ours, 25 cases of a-LyP have so far been reported. Clinically, a-LyP may present as acral involvement exclusively, in combination with mucosal lesions, (in itself a rare presentation), or in association with conventional LyP. The age of presentation was slightly higher than that of conventional LyP (55 vs 45 years) and a male predominance has been observed, as usually reported. Histopathologically, no morphological differences exclusively from conventional LyP were observed. LyP types A and E were the main variants. We describe for the first time one case of type D a-LyP. Acral LyP is a rare entity and correct diagnosis can only be reached with clinical and histopathological correlation, to avoid aggressive treatment of this indolent lymphoproliferative disorder.
Ki-1 Antigen/metabolism , Lymphomatoid Papulosis/pathology , Lymphoproliferative Disorders/pathology , Skin Neoplasms/pathology , Adolescent , Adult , Aged , Aged, 80 and over , Child , Diagnosis, Differential , Female , Humans , Immunohistochemistry/methods , Lymphomatoid Papulosis/diagnosis , Lymphomatoid Papulosis/metabolism , Lymphoproliferative Disorders/metabolism , Male , Middle Aged
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Humans , Male , Adult , Alopecia/etiology , Syphilis/diagnosis , Syphilis Serodiagnosis/methods , Treponema pallidum/pathogenicity
